Human Cytomegalovirus Superfamily Member in Virulent Strains of Cutting Edge: A Novel Viral TNF Receptor
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Cutting edge: a novel viral TNF receptor superfamily member in virulent strains of human cytomegalovirus.
The UL144 open reading frame found in clinical isolates of human CMV (HCMV) encodes a structural homologue of the herpesvirus entry mediator, a member of the TNFR superfamily. UL144 is a type I transmembrane glycoprotein that is expressed early after infection of fibroblasts; however, it is retained intracellularly. A YXXZ motif in the highly conserved cytoplasmic tail contributes to UL144 subc...
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Molecular mimicry of cytokines and cytokine receptors is a strategy used by poxviruses and herpesviruses to modulate host immunity. The human cytomegalovirus (HCMV) UL144 gene, situated in the UL/b0 region of the viral genome, has amino-acid sequence similarity to members of the tumour necrosis factor receptor superfamily. We report that UL144 is a potent activator of NFjB-induced transcription...
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تاریخ انتشار 1999